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1

P.2.25 GABAB receptors play a key role in the modulation of anxiety and antidepressant-related behaviour: genetic and pharmacological evidence

C. Mombereau, K. Kaupmann, W. Froestl, H. Van Der Putten, J.F. Cryan

Journal:

European Neuropsychopharmacology

Year:

2004

Language:

english

File:

PDF, 63 KB

english, 2004

2

Phosphinic acid analogues of γ-aminobutyric acid (GABA). Synthesis of a new radioligand

Roger G. Hall, Peter D. Kane, Helmut Bittiger, Wolfgang Froestl

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1995

Language:

english

File:

PDF, 252 KB

english, 1995

3

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors

Sébastien Guery, Philipp Floersheim, Klemens Kaupmann, Wolfgang Froestl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

4

Determination of the GABAB receptor agonist CGP 44532 (3-amino-2-hydroxypropylmethylphosphinic acid) in rat plasma after pre-column derivatization by micro-high-performance liquid chromatography combined with negative electrospray tandem mass spectrometry

W Blum, R Aichholz, P Ramstein, J Kühnöl, W Froestl, S Desrayaud

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

2000

Language:

english

File:

PDF, 334 KB

english, 2000

5

Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase

K. M. Gibson, D. S. M. Schor, M. Gupta, W. S. Guerand, H. Senephansiri, T. G. Burlingame, H. Bartels, B. M. Hogema, T. Bottiglieri, W. Froestl, O. C. Snead, M. Grompe, C. Jakobs

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 232 KB

english, 2002

6

Introduction to Receptors in Aging Diseases: GABAReceptors

Wolfgang Froestl

Journal:

Medicinal Chemistry Research

Year:

2004

File:

PDF, 131 KB

2004

7

The GABABantagonist CGP56433A attenuates the effect of baclofen on cocaine but not heroin self-administration in the rat

Karen Brebner, Wolfgang Froestl, David C. Roberts

Journal:

Psychopharmacology

Year:

2002

Language:

english

File:

PDF, 66 KB

english, 2002

8

The GABABreceptor agonists baclofen and CGP44532 decreased nicotine self-administration in the rat

NeilE. Paterson, Wolfgang Froestl, Athina Markou

Journal:

Psychopharmacology

Year:

2004

Language:

english

File:

PDF, 231 KB

english, 2004

9

Suppression of GABABreceptor function in vivo by disulfide reducing agent,dl-dithiothreitol (DTT)

Mauro A. M. Carai, Giovanni Vacca, Salvatore Serra, Giancarlo Colombo, Wolfgang Froestl, Gian Luigi Gessa

Journal:

Psychopharmacology

Year:

2004

Language:

english

File:

PDF, 198 KB

english, 2004

10

Effects of positive allosteric modulators of the GABABreceptor on cocaine self-administration in rats

MarkA. Smith, DavidL. Yancey, Drake Morgan, Yu Liu, Wolfgang Froestl, DavidC.S. Roberts

Journal:

Psychopharmacology

Year:

2004

Language:

english

File:

PDF, 214 KB

english, 2004

11

Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboons

Elise M. Weerts, Amy K. Goodwin, Roland R. Griffiths, P. Rand Brown, Wolfgang Froestl, Cornelis Jakobs, K. Michael Gibson

Journal:

Psychopharmacology

Year:

2005

Language:

english

File:

PDF, 287 KB

english, 2005

12

Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboons

Amy K. Goodwin, Wolfgang Froestl, Elise M. Weerts

Journal:

Psychopharmacology

Year:

2005

Language:

english

File:

PDF, 233 KB

english, 2005

13

Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons

Amy K. Goodwin, Roland R. Griffiths, P. Rand Brown, Wolfgang Froestl, Cornelis Jakobs, K. Michael Gibson, Elise M. Weerts

Journal:

Psychopharmacology

Year:

2006

Language:

english

File:

PDF, 462 KB

english, 2006

14

Reducing effect of the positive allosteric modulator of the GABABreceptor, GS39783, on alcohol self-administration in alcohol-preferring rats

Paola Maccioni, Daniela Pes, Alessandro Orrù, Wolfgang Froestl, Gian Luigi Gessa, Mauro A. M. Carai, Giancarlo Colombo

Journal:

Psychopharmacology

Year:

2007

Language:

english

File:

PDF, 232 KB

english, 2007

15

Repeated administration of the GABABreceptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats

Styliani Vlachou, Sebastien Guery, Wolfgang Froestl, Deboshri Banerjee, Jessica Benedict, M. G. Finn, Athina Markou

Journal:

Psychopharmacology

Year:

2011

Language:

english

File:

PDF, 294 KB

english, 2011

16

GABAB receptors in Schwann cells influence proliferation and myelin protein expression

Valerio Magnaghi, Marinella Ballabio, Ilaria T. R. Cavarretta, Wolfgang Froestl, Jeremy J. Lambert, Ileana Zucchi, Roberto C. Melcangi

Journal:

European Journal of Neuroscience

Year:

2004

Language:

english

File:

PDF, 309 KB

english, 2004

17

The GABAB receptor agonist CGP44532 and the positive modulator GS39783 reverse some behavioural changes related to positive syndromes of psychosis in mice

JM Wierońska, M Kusek, K Tokarski, J Wabno, W Froestl, A Pilc

Journal:

British Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 2.47 MB

english, 2011

18

Specific Reduction of Alcohol’s Motivational Properties by the Positive Allosteric Modulator of the GABAB Receptor, GS39783—Comparison With the Effect of the GABAB Receptor Direct Agonist, Baclofen

Paola Maccioni, Noemi Fantini, Wolfgang Froestl, Mauro A. M. Carai, Gian Luigi Gessa, Giancarlo Colombo

Journal:

Alcoholism: Clinical and Experimental Research

Year:

2008

Language:

english

File:

PDF, 309 KB

english, 2008

19

Reduction of Alcohol’s Reinforcing and Motivational Properties by the Positive Allosteric Modulator of the GABAB Receptor, BHF177, in Alcohol-Preferring Rats

Paola Maccioni, Mauro A.M. Carai, Klemens Kaupmann, Sébastien Guery, Wolfgang Froestl, Kimberly A. Leite-Morris, Gian Luigi Gessa, Giancarlo Colombo

Journal:

Alcoholism: Clinical and Experimental Research

Year:

2009

Language:

english

File:

PDF, 576 KB

english, 2009

20

10.1038/25360

Bettler, Bernhard, Kaupmann, Klemens, Malitschek, Barbara, Schuler, Valerie, Heid, Jakob, Froestl, Wolfgang, Beck, Pascal, Mosbacher, Johannes, Bischoff, Serge, Kulik, Akos, Shigemoto, Ryuichi, Karsch

Journal:

Year:

1998

Language:

english

File:

PDF, 2.29 MB

english, 1998

21

Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

Kaupmann, Klemens, Huggel, Katharina, Heid, Jakob, Flor, Peter J., Bischoff, Serge, Mickel, Stuart J., McMaster, Gary, Angst, Christof, Bittiger, Helmut, Froestl, Wolfgang

Journal:

Year:

1997

File:

PDF, 2.17 MB

1997

22

Comparison of antagonist potencies at pre- and post-synaptic GABAB receptors at inhibitory synapses in the CA1 region of the rat hippocampus

M F Pozza, N A Manuel, M Steinmann, W Froestl, C H Davies

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 179 KB

english, 1999

23

Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents

G Nowak, A Partyka, A Pałucha, B Szewczyk, J M Wierońska, M Dybała, M Metz, T Librowski, W Froestl, M Papp, A Pilc

Journal:

British Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 223 KB

english, 2006

24

Specific γ-hydroxybutyrate-binding sites but loss of pharmacological effects of γ-hydroxybutyrate in GABAB(1)-deficient mice

Klemens Kaupmann, John F. Cryan, Petrine Wellendorph, Cedric Mombereau, Gilles Sansig, Klaus Klebs, Markus Schmutz, Wolfgang Froestl, Herman Van Der Putten, Johannes Mosbacher, Hans Bräuner-Osborne, P

Journal:

European Journal of Neuroscience

Year:

2003

Language:

english

File:

PDF, 443 KB

english, 2003

25

ChemInform Abstract: Phosphinic Acid Analogues of GABA. Part 1. New Potent and Selective GABAB Agonists.

W. FROESTL, S. J. MICKEL, R. G. HALL, G. VON SPRECHER, D. STRUB, P. A. BAUMANN, F. BRUGGER, C. GENTSCH, J. JAEKEL, H.-R. OLPE, G. RIHS, A. VASSOUT, P. C. WALDMEIER, H. BITTIGER

Journal:

Year:

1995

Language:

english

File:

PDF, 40 KB

english, 1995

26

ChemInform Abstract: Phosphinic Acid Analogues of GABA. Part 2. Selective, Orally Active GABAB Antagonists.

W. FROESTL, S. J. MICKEL, G. VON SPRECHER, P. J. DIEL, R. G. HALL, L. MAIER, D. STRUB, V. MELILLO, P. A. BAUMANN, R. BERNASCONI, C. GENTSCH, K. HAUSER, J. JAEKEL, G. KARLSSON, K. KLEBS, L. MAITRE, C.

Journal:

Year:

1995

Language:

english

File:

PDF, 40 KB

english, 1995

27

Simultaneous determination of CGP 22 848 and its major metabolite (free carboxylic acid) CGP 35 652 in plasma by HPLC

A. Sioufi, F. Leroux, J. P. Dubois, C. Mondadori, W. Froestl

Journal:

Chromatographia

Year:

1987

Language:

english

File:

PDF, 374 KB

english, 1987

28

Enhancement of proteolytic processing of the β-amyloid precursor protein by hyperforin

Bettina Froestl, Barbara Steiner, Walter E. Müller

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 352 KB

english, 2003

29

SGS742: the first GABAB receptor antagonist in clinical trials

Wolfgang Froestl, Michela Gallagher, Helen Jenkins, Annette Madrid, Thorsten Melcher, Sam Teichman, Cesare G. Mondadori, Rodney Pearlman

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 347 KB

english, 2004

30

GABAB receptor positive modulators: Effects on nicotine self-administration and cue-induced reinstatement of nicotine-seeking behavior in rats

Styliani Vlachou, Sébastien Guery, Wolfgang Froestl, Klemens Kaupmann, Deboshri Banerjee, M.G. Finn, Athina Markou

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 72 KB

english, 2009

31

6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists

David Orain, Silvio Ofner, Manuel Koller, David A. Carcache, Wolfgang Froestl, Hans Allgeier, Vittorio Rasetti, Joachim Nozulak, Henri Mattes, Nicolas Soldermann, Philipp Floersheim, Sandrine Desrayau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 510 KB

english, 2012

32

In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptor

Mauro A.M. Carai, Giancarlo Colombo, Wolfgang Froestl, Gian Luigi Gessa

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 120 KB

english, 2004

33

Reducing effect of the positive allosteric modulators of the GABAB receptor, CGP7930 and GS39783, on alcohol intake in alcohol-preferring rats

Alessandro Orrù, Paola Lai, Carla Lobina, Paola Maccioni, Patrizia Piras, Laura Scanu, Wolfgang Froestl, Gian Luigi Gessa, Mauro A.M. Carai, Giancarlo Colombo

Journal:

European Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 372 KB

english, 2005

34

Influence of a GABAB and GABAC receptor antagonist on sleep–waking cycle in the rat

Olivier Deschaux, Wolfgang Froestl, Claude Gottesmann

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 196 KB

english, 2006

35

Both GABAB receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats

Styliani Vlachou, Neil E. Paterson, Sebastien Guery, Klemens Kaupmann, Wolfgang Froestl, Deboshri Banerjee, M.G. Finn, Athina Markou

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 440 KB

english, 2011

36

Effects of GABAB receptor antagonism on the development of Pentylenetetrazol-induced kindling in mice

Damianka Getova, Wolfgang Froestl, Norman George Bowery

Journal:

Year:

1998

Language:

english

File:

PDF, 567 KB

english, 1998

37

Comparative activities of the enantiomeric GABAB receptor agonists CGP 44532 and 44533 in central and peripheral tissues

Jennifer Ong, Sotiria Bexis, Victor Marino, David A.S Parker, David I.B Kerr, Wolfgang Froestl

Journal:

European Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 318 KB

english, 2001

38

CGP 36216 is a selective antagonist at GABAB presynaptic receptors in rat brain

Jennifer Ong, Sotiria Bexis, Victor Marino, David A.S Parker, David I.B Kerr, Wolfgang Froestl

Journal:

European Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 82 KB

english, 2001

39

Morpholin-2-yl-phosphinic acids are potent GABAB receptor antagonists in rat brain

Jennifer Ong, David I.B. Kerr, Helmut Bittiger, Peter C. Waldmeier, Peter A. Baumann, Nigel G. Cooke, Stuart J. Mickel, Wolfgang Froestl

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 321 KB

english, 1998

40

Comparative potencies of CGP 47654A and CGP 46165A as GABAB receptor antagonists in rat brain

Jennifer Ong, David I.B Kerr, Wolfgang Froestl

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 168 KB

english, 1999

41

Pharmacological re-evaluation of a GABAB receptor antagonist CGP 47332A in rat brain

Jennifer Ong, Victor Marino, David A.S Parker, David I.B Kerr, Wolfgang Froestl

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 103 KB

english, 1999

42

Ligands for expression cloning and isolation of GABAB receptors

Wolfgang Froestl, Bernhard Bettler, Helmut Bittiger, Jakob Heid, Klemens Kaupmann, Stuart J. Mickel, Dietrich Strub

Journal:

Year:

2001

Language:

english

File:

PDF, 134 KB

english, 2001

43

Ligands for expression cloning and isolation of GABAB receptors

Wolfgang Froestl, Bernhard Bettler, Helmut Bittiger, Jakob Heid, Klemens Kaupmann, Stuart J. Mickel, Dietrich Strub

Journal:

Year:

2003

Language:

english

File:

PDF, 421 KB

english, 2003

44

Receptors in neurodegenerative diseases

Wolfgang Froestl

Journal:

Pharmaceutica Acta Helvetiae

Year:

2000

Language:

english

File:

PDF, 83 KB

english, 2000

45

Novel GABAB receptor positive modulators: a patent survey

Froestl, Wolfgang

Journal:

Expert Opinion on Therapeutic Patents

Year:

2010

Language:

english

File:

PDF, 614 KB

english, 2010

46

CGP 35348: a centrally active blocker of GABAB receptors

Hans-Rudolf Olpe, Göril Karlsson, Mario F. Pozza, Felix Brugger, Martin Steinmann, Henk Van Riezen, Graham Fagg, Roger G. Hall, Wolfgang Froestl, Helmut Bittiger

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 809 KB

english, 1990

47

The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro

Hans-Rudolf Olpe, Martin W. Steinmann, Thomas Ferrat, Mario F. Pozza, Karin Greiner, Felix Brugger, Wolfgang Froestl, Stuart J. Mickel, Helmut Bittiger

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 687 KB

english, 1993

48

The action of new potent GABAB receptor antagonists in the hemisected spinal cord preparation of the rat

Felix Brugger, Urs Wicki, Hans-Rudolf Olpe, Wolfgang Froestl, Stuart Mickel

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 240 KB

english, 1993

49

Effects of GABAergic modulators on food and cocaine self-administration in baboons

Elise M. Weerts, Wolfgang Froestl, Roland R. Griffiths

Journal:

Drug and Alcohol Dependence

Year:

2005

Language:

english

File:

PDF, 158 KB

english, 2005

50

Attenuation of cocaine-seeking by GABAB receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons

Elise M. Weerts, Wolfgang Froestl, Barbara J. Kaminski, Roland R. Griffiths

Journal:

Drug and Alcohol Dependence

Year:

2007

Language:

english

File:

PDF, 239 KB

english, 2007

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